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"根据结构特征,MMPs可分为: 胶原酶(collagenases)" 的 英語 翻譯

根据结构特征,MMPs可分为: 胶原酶(collagenases),包括MMP-1、MMP-8、MMP-13,底物有Ⅰ、Ⅱ、Ⅲ、V、Ⅸ型胶原,nidogen,腱生蛋白(tenascin)和纤维粘连蛋白; 明胶酶(gelatinases),包括MMP-2和MMP-9,降解Ⅳ、V、Ⅶ、X、Ⅺ及XⅣ型胶原,明胶、弹力蛋白、蛋白多糖以及纤维粘连蛋白; 基质溶解素( stromelysins),包括MMP-3、MMP-10和MMP-11,底物有Ⅲ、Ⅳ、V、Ⅶ、Ⅸ及X型胶原,弹力蛋白、纤维粘连蛋白以及rudogen; 间质溶素(matrilysins),包括MMP-7和MMP-26,是最小的MMPs,底物有Ⅳ型胶原、弹力蛋白、纤维粘连蛋白和腱生蛋白; 模型MMPs(MT-MMPs),不同于其他MMPs。模型MMPs有跨膜功能区,表达在细胞膜表面(尾端在胞质内)。成员包括MMP-14、MMP-15、MMP -16、MMP-17、MMP-24和MMP-25,底物不一。 参考TSU.TW原文:https://www.tsu.tw/pfb/jichu/xbfz/ecm/1017.html

According to the structural characteristics, MMPs can be classified as collagenases, including MMP-1, MMP-8 and MMP-13. Substrates include collagen type I, II, III, V, IX, nidogen, tenascin and fibronectin; gelatinases, including MMP-2 and MMP-9, degrade type IV, V, _, X, _and XIV gums. Proto, gelatin, elastin, proteoglycan and fibronectin; stromelysins, including MMP-3, MMP-10 and MMP-11, with collagen III, IV, V, _, IX, elastin, fibronectin and rudogen; matrix lysins, including MMP-7 and MMP-26, are The smallest MMPs were collagen type IV, elastin, fibronectin and tendinogenesis; the model MMPs (MT-MMPs) were different from other MMPs. The model MMPs had transmembrane functional regions and expressed on the surface of cell membrane (the tail end was in the cytoplasm). The members included MMP-14, MMP-15, MMP-16, MMP-17, MMP-24 and MMP-25, but the substrate was not. 1. Refer to the original text of TSU.TW: https://www.tsu.tw/pfb/jichu/xbfz/ecm/1017.html

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